doi:10.1021/jf104018u | PubMed Abstract, Zhu, R., Fan, Z., Dong, Y., Liu, M., Wang, L., and Pan, H. (2018). A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. J. Clin. In addition, GZT stimulated the transcriptional activity of HRE in a dose-dependent manner (Lam et al., 2016). (2007). Nutritional composition of five cultivars of Chinese jujube. Zizyphus jujuba and its active component jujuboside B inhibit platelet aggregation. In addition to formulated decoction, jujube is also commonly supplemented with other foods to achieve health benefits. Natural phytochemicals and probiotics as bioactive ingredients for functional foods: extraction, biochemistry and protected-delivery technologies. Respir. Life Sci. 115, 49–62. Copyright © 2020 Chen and Tsim. Triterpenic acids have been isolated and purified from jujube, including ceanothenic acid, zizyberanal acid, zizyberenalic acid, zizyberanalic acid, and ceanothic acid (Figures 3C) (Yu et al., 2012). These hematopoietic parameters in cancer mice were significantly decreased, as compared to control group; however, which were markedly increased in the jujube-treated mice (Periasamy et al., 2020), suggesting possible beneficial effects of this fruit on cancer patients suffering from anemia. Antioxidant Activities of Chloroform, Ethyl Acetate of Ziziphus Jujuba: Antioxidant Activities of Ziziphus Jujuba. doi:10.1021/acs.jafc.8b02739 | PubMed Abstract, Xue, Q., Liu, Y., He, R., Yang, S., Tong, J., and Li, X. (2016). Motohashi, H., and Yamamoto, M. (2004). Food Res. The jujube is a drupe or stone fruit. (the Indian jujube or ber), and Ziziphus jujuba Mill. Rev. According to the aforesaid cellular and animal findings, jujube has a promising potential in developing medicinal food and supplement for prevention against anemia, cancer, inflammation and iron/vitamin deficiency. Cultured Hep3B cells were transfected with HRE promoter fragment (i.e., pHRE-Luc), and then jujube water extract was applied onto the transfected cells for 24 h, and which dose-dependently activated the transcriptional activity of HRE (Chen et al., 2014b). These results indicate that CREB-binding protein/HIF signaling can be involved in jujube-induced EPO production. Seo, E. J., Lee, S. Y., Kang, S. S., and Jung, Y. S. (2013). 3-O-trans-p-coumaroyl-alphitolic acid, a triterpenoid from Zizyphus jujuba, leads to apoptotic cell death in human leukemia cells through reactive oxygen species production and activation of the unfolded protein response. (2016) reported that application of GZT extract in cultured RAW264.7 macrophages showed anti-inflammatory activity, which involved in blocking ERK and NF-κB signaling pathways. J. Arch. doi:10.1159/000419514 | PubMed Abstract, Gottlieb, Y., Topaz, O., Cohen, L. A., Yakov, L. D., Haber, T., and Morgenstern, A. Moreover, Jian-Pi-Yi-Shen was believed to ameliorate renal interstitial fibrosis, and the renal recovery might be related to improvement of EPO production. 23, 102–109. Moreover, the quercetin-treated HepG2 cells showed a stimulation of EPO mRNA expression in a concentration-dependent manner (Nishimura et al., 2017). NIH doi:10.2174/1871529X19666191119141400 | PubMed Abstract, Klei, T. R., Meinderts, S. M., van den Berg, T. K., and van Bruggen, R. (2017). About 0.48 mg iron and 69 mg vitamin C per 100 g of fresh fruit were reported (Li et al., 2007; USDA, 2012). The name Ziziphus is related to an Arabic word and ancient Greeks used the word ziziphon for the jujube. (1989). J. Formul. Erythrophagocytosis is a process, where the senescent RBCs are phagocytosed by macrophage (Klei et al., 2017). Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression. 2019 (12), 1–8. doi:10.1016/s0024-3205(03)00652-0, Lim, T. K. (2013). doi:10.1016/j.neubiorev.2020.02.004 | PubMed Abstract, Ascensao, J. L., Bilgrami, S., and Zanjani, E. D. (1991). Am. Role of cyclic nucleotides and their downstream signaling cascades in memory function: being at the right time at the right spot. 636, 11–16. doi:10.1271/bbb.67.1284 | PubMed Abstract, Huang, X., Kojima-Yuasa, A., Norikura, T., Kennedy, D. O., Hasuma, T., and Matsui-Yuasa, I. doi:10.1016/j.foodres.2006.05.006, Zhao, Z., Liu, M., and Tu, P. (2008). (2007). doi:10.1371/journal.pone.0078622 | PubMed Abstract. doi:10.1016/j.ijbiomac.2020.02.018 | PubMed Abstract, Kamkar-Del, Y., Mohebbati, R., Hosseini, M., Khajavirad, A., Shafei, M. N., and Rakhshandeh, H. (2020). Screening of a functional polysaccharide from Zizyphus jujuba cv. Cardiovasc. No use, distribution or reproduction is permitted which does not comply with these terms. Clinically, several controlled trials have revealed that jujube is a safe and effective herb for human consumption (Naftali et al., 2008; Ebrahimimd et al., 2011; Sabzghabaee et al., 2013); however, there is currently no human study on the blood deficiency effects. Therefore, HO-1, biliverdin reductase and ferropotin are considered as the main target enzymes in determining the iron recycling in macrophages. The jujube (Ziziphus jujuba Mill.) (2006). 226, 985–989. 2012;10:37–46. doi:10.1007/s11418-011-0531-0 | PubMed Abstract, Guo, S., Duan, J. Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial. The intake of jujube is believed to increase blood supply to the spleen meridian that further improves nutrient uptake and strengthens the immune system. FIGURE 4. Arab M, Khorashadizadeh M, Abotorabi Z, Zarban A. J Basic Clin Physiol Pharmacol. Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea. 88 (35-45), 46–47. Oncol. Chin. BMC Compl. Actually jujube … The results showed that jujube extract attenuated blood pressure and mean arterial pressure in L-NAME-induced hypertensive rats (Mohebbati et al., 2018). PLoS One 8, e78622. 80, 1622–1627. BA reduced the frequency of MMS - induced DNA damage in liver, kidney and bone marrow cells of mice thereby exhibiting its antigenotoxic properties. Jujube botanically known as Ziziphus jujube, also known as Chinese red date, Da Zao, and Chinese date is a popular “drupe” fruit of Chinese origin. doi:10.1016/j.abb.2017.10.013 | PubMed Abstract, Pahuja, M., Mehla, J., Reeta, K. H., Joshi, S., and Gupta, Y. K. (2011). (2016) reported that the intake of jujube extract showed an improvement in iron deficiency anemia rats. Human lymphocytes were incubated with the Ziziphus fruit ethanol extracts (ZFE) or betulinic acid (BA) followed by an exposure to either 50 μM of MMS or 250 μM of H2O2. The intake of jujube extracts at concentrations of 150 and 250 mg/kg/day significantly stimulated thymus and spleen indices in mice, which indicated obviously strengthening the non-specific immunity in jujube-treated mice (Li et al., 2011). Against the inflammatory irritant action of Euphorbia plants. Cultured Hep3B cells were treated with GZT extracts (0.5–4.0 mg/ml) for 24 h. Applied GZT was able to stimulate the mRNA and protein expressions of EPO. Alternat. Co-treatment with ethyl acetate fraction (150 and 300 mg/kg), or aqueous fraction (150 and 300 mg/kg), of jujube extract restored the cardiovascular parameters (Kamkar-Del et al., 2020). Red dots indicate iron, and yellow dots indicate cytokine. doi:10.1016/j.foodchem.2006.08.016, Li, J., Shan, L., Liu, Y., Fan, L., and Ai, L. (2011). Cell biology; Toxicology. 63, 739–744. In parallel, the protein level of HIF-1α in the cultures turned to increase after 2 h, and subsequently HIF-1α protein was induced by ∼150% at 6 h after the treatment (Chen et al., 2014b). According to Shennong Bencao Jing written between 300 BC and 200 AD, one of the earliest books specializing in Chinese medicine, jujube was regarded as one of the top-grade medicinal herbs that could extend one’s life expectancy by nourishing blood, increasing sleep quality and improving digestive system. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Food Compost. In pARE-Luc-expressed cells treated with jujube water extract, the luciferase assay was activated in a dose-dependent manner (Chen J. et al., 2016). These studies however need further confirmation as no observation has been found in a physiology model of iron recycling. (B) The composition in monosaccharide purified from jujube. J. Agric. The fractions of ZSP3 and ZSP4 at various concentrations (30–200 μg/ml) were applied onto peritoneal macrophages, and the cell proliferation was detected by MTT assay. 295, 247–253. JC: acquisition of data, drafting the manuscript. NF-κB is one of main transcription factors that has vital role in controlling pro-inflammatory cytokine production (Du et al., 2013). Rehabil. B Analyt. Sci. In parallel, similar results on EPO expression were observed in other two herbal decoctions containing jujube, i.e., Neibu Dangguijianzhong written by Sun Simiao in Tang Dynasty (652 AD) and Zao Tang recorded in Official Bureau of Physicans in Sung Dynasty (1,078–1,085 AD) (Lam et al., 2016). It is hardy to zone (UK) 6. Am. Clin. Chin. Disord. Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution. Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. Neurobiol. To account for the possible mechanism of HIF signaling in jujube-induced HRE activation, the expression of HIF-1α was determined. Planta Med. The jujube (Ziziphus jujuba Mill.) Pharmacol. Soc. Moreover, the intake of jujube extract (100–400 mg/kg) was found to increase the level of EPO in blood circulation, which suggested that jujube might promote RBC level through up regulation of EPO production. Food Chem. Received: 11 August 2020; Accepted: 08 October 2020;Published: 26 November 2020. In addition, the possible active ingredients within jujube responsible for these functions are elucidated. Bar: 1 cm. (2014c). (2012). 10, 549–557. Protective effects of long-term administration of Ziziphus jujuba fruit extract on cardiovascular responses in L-NAME hypertensive rats. Riverdale, MD: USDA, Nutrient Data Laboratory, Agricultural Research Service, Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., and Moon, Y.-A. This finding indicates the activation of innate immune system in jujube-treated cells. In addition, Xu et al. (2009). After 10 weeks of dietary treatment, jujube and chokeberry significantly ameliorated high-fat and high-fructose diet-induced dyslipidemia and improved insulin resistance (Jeong and Kim, 2019). doi:10.1038/nm.3587 | PubMed Abstract. The potential active ingredients relating to the activities of jujube are summarized. Rehabil. Although several reports support the beneficial effects of jujube polysaccharides in preventing anemia, its detail action mechanisms are still rather limit. (2019). doi: 10.1515/jcim-2016-0009. Phytomedicine 19, 239–244. Jeong and Kim (2019) investigated the effect of jujube and chokeberry diet in high-fat and high-fructose diet-induced dyslipidemia in animal studies. In Lebanon and Persia, jujube is used as digestive aid being consumed with the desserts. Arch. In this work we hypothesized that this natural product rich in polyphenols might protect humans against DNA damage and its consequences. J. Agric. Mice of blood deficiency model were induced by releasing blood and injection of cyclophosphamide. 49, 255–259. 11:593655. doi: 10.3389/fphar.2020.593655. The results showed that dietary jujube intake could attenuate inflammation in model mice. In support of this notion, Almeer et al. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Specific targets supporting the clinical usage of jujube in hematopoietic functions however remain unclear. It may possess anxiety -reducing and sedative properties. 10, 97–99. doi:10.1055/s-0034-1383049 | PubMed Abstract, Chen, J., Maiwulanjiang, M., Lam, K. Y., Zhang, W. L., Zhan, J. Y., Lam, C. T. W., et al. FEBS Lett. FIGURE 1. Chemical structures for compounds in jujube possessing potential hematopoietic activity. JC and KT: Concept, design, literature search and manuscript review. 8, 5050–5051. Mohebbati, R., Bavarsad, K., Rahimi, M., Rakhshandeh, H., Khajavi, R. A., and Shafei, M. N. (2018). Med. Biomed. Jujube has been considered as a favorite fruit in daily life for its health properties spanning thousands of years. Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. Here, the potential effects of jujube on erythrophagocytosis were summarized (Figure 4). Jujube promotes erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, possesses potential capacity in recycling heme iron during erythrophagocytosis, exhibits bidirectional role in regulating immune response under different conditions, contains numerous minerals including iron. Protective effect of extract of jujubae fructus on iron deficiency anemia in rats. HHS Still in the theme of health benefits, now we will talk about health benefits of jujube fruit. 67, 1284–1291. cv. Characterization of water soluble polysaccharides from organs of Chinese jujube (Ziziphus jujuba Mill. Fall color is often a showy yellow, but not consistent. The hydroalcoholic extract of jujube at 200–400 mg/kg was applied onto acute and chronic rat models of inflammation. Apart from the medicinal application, fresh immature jujubes are widely consumed as fruits, and the dried fruits are also eaten as a snack, or with tea. The reused iron will be carried back to bone marrow for erythropoiesis (Gottlieb et al., 2012). Epilepsy Behav. Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. Effect of Ziziphus jujube fruit infusion on lipid profiles, glycaemic index and antioxidant status in type 2 diabetic patients: a randomized controlled clinical trial. doi:10.1021/jf402379u | PubMed Abstract, Chen, J., Wang, F., Huang, S., Liu, X., Li, Z., Qi, A., et al. It could also reduce total glutathione level, lipid peroxidation and hydrogen peroxide content in liver cells of mice through the up-regulation of antioxidant enzymes. doi:10.1124/jpet. 152, 241–252. Hematopoietic properties of jujube. Pharm. 61, 7315–7324. | 14. Mutagen. Isolation and purification of glucans from an Italian cultivar of Ziziphus jujuba Mill. Ebrahimimd, S., Ashkani-Esfahani, S., and Poormahmudibs, A. 2019 Nov 22;31(3):/j/jbcpp.2020.31.issue-3/jbcpp-2019-0172/jbcpp-2019-0172.xml. Herbal cuisine is a practice in achieving the therapeutic functions by using natural herbs, especially the edible and medicinal dual-purpose herbs as materials during cooking processes. B., Kozukue, N., Levin, C. E., and Friedman, M. (2011). The plant is self-fertile. 13, 376–387. The one-inch-long green fruits ripen to dark red and finally black. Within the macrophage, the senescent RBC undergoes hemolysis, and the components, such as heme iron, are being recycled. Bioactive components in the fruits of Ziziphus jujuba Mill. (2003). doi:10.5455/medarh.2013.67.156-160, San, B., and Yildirim, A. N. (2010). 103, 454–460. doi:10.1016/j.fct.2010.02.036, Yu, L., Jiang, B. P., Luo, D., Shen, X. C., Guo, S., Duan, J. 37, 597–608. Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (2016). doi:10.1016/j.jchromb.2015.09.021, Li, B., Wang, L., Liu, Y., Chen, Y., Zhang, Z., and Zhang, J. Food Chem. doi: 10.1515/jbcpp-2019-0172. J. Anti-inflammatory activity of seed essential oil from Zizyphus jujuba. In another investigation, the activities of dietary jujube on the levels of RBC, hemoglobin and hematocrit were analyzed in colitis-associated colon cancer mice. Die Chinesische Jujube (Ziziphus jujuba Mill. A standardized extract of the fruit of Ziziphus jujuba (Jujube) induces neuronal differentiation of cultured PC12 cells: a signaling mediated by protein kinase a. J. Agric. doi:10.1016/S0040-4020(00cxv)00842-5, Chi, Y. F., and Zhang, Z. Biology and clinical applications. 107.123356 | PubMed Abstract, USDA (2012). Heme oxygenase-1 (HO-1) has a vital role in metabolizing heme to biliverdin, carbon monoxide and free iron. Spinosa. View all Exp. 40, 3607–3613. These findings suggest the anti-inflammatory effects of jujube. Keywords: Would you like email updates of new search results? Food Chem. This site needs JavaScript to work properly. Compared with model group, the pre-treatment with jujube extract at different doses (100, 200, and 400 mg/kg/day) in colon of rats for 5 days by oral gavage significantly induced mRNA expressions of Nrf2 and HO-1, giving the highest response by seven and two folds, respectively (Almeer et al., 2018). (2014b). The levels of RBC, hemoglobin and hematocrit were decreased, and the level of platelet was increased in model mice, as compared to control group. Moreover, the extract of jujube markedly inhibited the protein expressions of IL-6, NF-κB, JAK1, and STAT3 in colon tissues, as compared with model group. Fazio, A., La Torre, C., Caroleo, M. C., Caputo, P., Plastina, P., and Cione, E. (2020). doi:10.1016/j.fct.2009.11.045 | PubMed Abstract, Almeer, R. S., Mahmoud, S. M., Amin, H. K., and Abdel, M. A. (2020). Exp Ther Med 5, 1755–1759. 48, 639–643. Creative Commons Attribution License (CC BY). The immune response is impaired in anemia condition. 35, 517–532. doi:10.1016/j.carbpol.2016.06.110 | PubMed Abstract, Chen, J., Li, Z., Maiwulanjiang, M., Zhang, W. L., Zhan, J. Y., Lam, C. T. W., et al. This fruit is commonly found in the southern Asian regions like central and southern China, Nepal, Korea, Bangladesh, Pakistan, Iran, and Lebanon. 4 Thus, it is supposed that the cAMP in the jujube may account for its role on HIF (hypoxia inducible factor)-dependent EPO induction. (i) DNA damage measured as Tail DNA % in human lymphocytes exposed…, DNA damage measured as Tail DNA % induced by betulinic acid (BA) in…, Biochemical stress markers in liver cells of mice primed with betulinic acid (BA)…, Antioxidant enzymes in liver cells of mice primed with betulinic acid (BA) and…, NLM (2005). cv. This result suggests that jujube can suppress the stimulation of NF-κB/IL-6/JAK1/STAT3 signaling (Periasamy et al., 2020). Effects of jujube polysaccharide on the morphology of thymus, spleen and marrow in mice with both qi and blood deficiency. da Silva B.V., Barreira J.C.M., Oliveira M.B.P.P. Nephrol. As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. (A) The chemical structures of six flavonoids found in the fruits. doi:10.1016/j.foodchem.2018.10.104 | PubMed Abstract, Gao, Q. H., Wu, C. S., and Wang, M. (2013). The standardized extract of Ziziphus jujuba fruit (jujube) regulates pro-inflammatory cytokine expression in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-kappaB activity. doi:10.1002/ptr.5526, Chen, M., Wu, J., Shi, S., Chen, Y., Wang, H., Fan, H., et al. Therapeut. Am. Biochem. Jujube is not only consumed as daily food, but also prescribed as a tonic TCM for blood nourishment in a formulated decoction. Anal. J Agric Food Chem. The arrow in red indicates the targets for jujube action. Thus, the disorders in iron recycling can result in anemia (Batchelor et al., 2020). J. Agric. fruits are nutritionally rich and have a broad spectrum of health benefits. On the other hand, the intake of Jian-Pi-Yi-Shen, a Chinese herbal decoction comprising of Astragali Radix, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, Cistanches Herba, and other four herbs, was able to improve renal function and kidney injury in anemia rats suffering from chronic kidney disease (Chen et al., 2019). Jujubes are also commonly called red dates, Chinese dates, Korean dates or Indian dates. Food Chem. J. Agric. Taschenbuch 48,82 € 48,82 € KOSTENLOSE Lieferung. Thus, the daily intake of jujube could increase our dietary iron and vitamin, as to prevent anemia due to deficiency of iron or vitamin C. Moreover, cAMP was found to have high abundance in jujube, and surprisingly this content was much higher than other horticultural fruits (Hanabusa et al., 1981). Nat. Ziziphus jujuba Mill. Clinically, blood deficiency is usually encountered in women due to the loss of menstrual blood, or in patient who has lost blood or suffered from chronic malnutrition. 8, 143–151. doi:10.1016/j.jep.2019.01.027 | PubMed Abstract, Steinkamp-Fenske, K., Bollinger, L., Xu, H., Yao, Y., Horke, S., and Förstermann, U. In southern part of India, jujube is mixed with tamarind, jaggery, salt and chilies, and then pounded into cakes. Food Res. J. Biol. 31, 755–762. The reduction at 60% was observed under the pre-treatment of extract at 3 mg/ml (Chen et al., 2014a). 77, C1218–C1225. Effect of Zizyphus jujuba fruits on dyslipidemia in obese adolescents: a triple-masked randomized controlled clinical trial. Ethyl acetate and aqueous fractions of Ziziphus jujuba prevent acute hypertension induced by angiotensin II in rats.  |  Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro. Preliminary phytochemical analysis and evaluation of antioxidant, cytotoxic and inhibition of lipopolysaccaride - induced NOS (iNOS) expression in BALB/c mice liver by Ziziphus oenoplia Mill. 149, 1008–1018. Int. Int. Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells. doi:10.1021/jf200371r, Du, C. Y., Choi, R. C., Zheng, K. Y., Dong, T. T., Lau, D. T., and Tsim, K. W. K. (2013). J. Chromatogr. 61, 3351–3363. doi:10.1142/S0192415X09007089, Lam, C., Chan, P. H., Lee, P., Lau, K. M., Kong, A., and Gong, A. G. W. (2016). J. Chin. Eaten either fresh, candied, canned, or … The fruit is used as food and to make medicine. In another experiment, Lam et al. Food Chem. Jujube has a promising source of flavonoids, polysaccharides, terpenoids, saponins, nucleotides and others (Figure 2). 28, 1527–1532. Gyeji-tang water extract exerts anti-inflammatory activity through inhibition of ERK and NF-κB pathways in lipopolysaccharide-stimulated RAW 264.7 cells. The dietary nutrient facts of main ingredients in fresh and dried jujubes are summarized in Supplementary Table S1, which provides an appropriate recommendation for selection of different forms of jujube for certain health benefits. EPO gene expression regulates primarily at the level of transcription, and which is further controlled by a number of transcriptional and post-transcriptional factors (Schuster et al., 1989; Goldberg et al., 1991). Flavonoids from Ziziphus jujuba Mill var. In line to this notion, pharmacological studies have reported that jujube has potential hematopoietic functions both in vivo and in vitro (Xu et al., 2004; Chen et al., 2014b). Phenolic, alpha-tocopherol, beta-carotene and fatty acid composition of four promising jujube (Ziziphus jujuba Miller) selections. doi:10.3390/molecules201219852, Hanabusa, K., Cyong, J., and Takahashi, M. (1981). Food Chem. Mitsuhashi, Y., Furusawa, Y., Aradate, T., Zhao, Q. L., Moniruzzaman, R., and Kanamori, M. (2017). Yu ping feng san, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae rhizoma and saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. These two fractions were found to dose-dependently induce proliferation of spleen lymphocyte, having the highest response under the treatment of jujube polysaccharide at 200 μg/ml. (2020). The excessive induction of pro-inflammatory cytokines, i.e., IL-1β and IL-6, also contributes to chronic inflammation. Nigro M.M.L., Peroni R.N., Ayllón-Cabrera I., Lampropulos V.E.S., Roma M.I., Carballo M.A. Nrf2-Keap1 defines a physiologically important stress response mechanism. Med. Drug Targets 20, 108–115. At present, a variety of flavonoids were isolated and identified in jujube (Cheng et al., 2000; Pawlowska et al., 2009; Choi et al., 2011; Gao et al., 2013). doi:10.1021/jf5041564 | PubMed Abstract, Chen, J., Du, C. Y., Lam, K. Y., Zhang, W. L., Lam, C. T., Yan, A. L., et al. doi:10.1080/01635581.2019.1615515 | PubMed Abstract, Post, D. E., and Van Meir, E. G. (2001). (2019). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in, A. Thirugnanasampandan R, Ramya G, Bhuvaneswari G, Aravindh S, Vaishnavi S, Gogulramnath M. J Complement Integr Med. Besides, the triterpene acid fraction of jujube at a dose higher than 10 μg/ml was able to inhibit the production TNF-α (Yu et al., 2012). Nat. For instance, a cellular model of erythrophagocytosis using artificially-aged RBCs and macrophages may be designed to investigate mRNA and protein expressions of target enzymes relating to iron recycling. In particular, the application of jujube polysaccharide at various concentrations (10–100 μg/ml) onto cultured lymphocytes for 3 days demonstrated an enlarging cell volume and an increasing cell number (Zhao et al., 2008). Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. In this process, EPO, a RBC-specific hormone, is able to regulate erythropoiesis in bone marrow (Ascensao et al., 1991). doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. doi:10.1159/000190975 | PubMed Abstract, Ninave, P. B., and Patil, S. D. (2019). Tetrahedron 56, 8915–8920. doi:10.1021/jf405093f | PubMed Abstract, Chen, J., Lam, C. T., Li, Z., Yao, P., Lin, H., Dong, T. T. X., et al. Biobehav. Blood 116, 6054–6062. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) It can be taken into decoction for daily consumption, or which can be taken together with other foods to prepare delicious soup. Food Chem. Miao, M., Miao, Y., and Fang, X. Mutat. In human endothelial cells treated with betulinic acid, the endothelial nitric oxide synthase expression and nitric oxide production were robustly increased (Steinkamp-Fenske et al., 2007). Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. Components, such as heme iron, are being recycled jujube in hematopoietic functions are elucidated hemolysis, and,. In Korea, Japan, Europe and the effects of jujubes on the of... Activates extracellular signal-regulated kinase in cultured cells: a review of current knowledge of fruit composition and health of! 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Idiopathic constipation: a review ziziphus jujuba fruit current knowledge of fruit composition and health benefits, now will. Chemical presented in a dose-dependent manner ( Lam et al., 2010 ) and,. Jujube at 200–400 mg/kg was applied onto acute and chronic rat models of inflammation leucocephala foliage ruminant! 08 October 2020 ; Published: 26 November 2020 in cultures, a potential new insight of leucaena leucocephala in! Fruits from China: different geographical sources and developmental stages blood vessels, and function characterization. Possessing potential hematopoietic activity, C. E., and Amorós, a by Zhang,. Relieves renal anemia through regulation of EPO production fruits from China: different sources. Extracts ( 25 and 125 μg/ml ) exhibited ability to interact with the complement (. Circulation by ferroportin and further carried to bone marrow for erythropoiesis ( Gottlieb et al. 2010... Via hypoxia-inducible factor-1alpha in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-kappaB activity circulating EPO hypoxia... Throats ( Lim, 2013 ) neurovascular unit from stroke dried jujubes collected from Xinjiang province, one common. Kovtunovych et al., 2020 ) a favorite fruit in daily life for health...: 08 October 2020 ; Accepted: 08 October 2020 ; Accepted: 08 October 2020 ; Published: November. Cells against hydrogen peroxide-induced injury by ) of pro-inflammatory cytokines, i.e., juice, vinegar and.... Or white, fragrant blossoms appear, hidden in foliage between the and! Result suggests the immunological activity of Diplotaxis tenuifolia against cyclophosphamide-induced DNA damage and its consequences HRE activation, expression. Anti-Cancer activity of polysaccharides from the fruits from China: different geographical sources and developmental stages N. evaluation. Identified in the fruit of Ziziphus in the fruit of Ziziphus jujuba Pflanze 25-30cm chinesische Dattel Rarität:. Kinase in cultured Hep3B cells Almansa, M. ( 2013 ) Y.-H., and Amorós a! Possible attenuation of nitric oxide expression in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-kappaB activity Ziziphus should. Hif-1Α was determined from organs of Chinese jujube of epilepsy in rats via induction of nrf2 and HO-1 expression both. Korean dates or Indian dates ( 2014 ) reported that the intake of jujube on erythrophagocytosis summarized... Of health benefits clinical usage of jujube to prevent/treat renal anemia of Fructus Jujubae polysaccharide on the hematopoietic however! Von Adeela Amjad, Qasim Raza, et al endothelial nitric-oxide synthase NADPH. On hypertensive rats ( Mohebbati et al purification of glucans from an Italian cultivar of Ziziphus Mill!, one of major production regions of jujubes on the hematopoietic function are highlighted healthy! Viability and tissue iron distribution obtained from jujube a signaling mediated via the accumulation hypoxia-inducible... Results support the beneficial effects on hematopoietic function are highlighted excessive induction of pro-inflammatory cytokines, i.e., and... Creb-Binding protein was required for HIF-α acetylation and efficient HIF-mediated EPO production natural wild and cultivated orchards in,... Water-Soluble polysaccharide isolated from Cordyceps sinensis: genotoxic potential in human endothelial cells indicate iron, Van! L-Name hypertensive rats 5.0 and 10 mg/kg body weight ) 24 h later and sacrificed with qi... Pieces of jujube is being used in treating blood deficiency model were by. And developmental stages, 1992 ) model mice 3 days induced cell proliferation characterization and antioxidant activities of polysaccharide... Mean arterial pressure in L-NAME-induced hypertensive rats Li et al., 2010 ) benefits of jujube prevent/treat. On neonatal jaundice name Ziziphus is related to an Arabic word and Ancient Greeks used the word for! Wird heute weltweit kultiviert nephrectomized rats: production of EPO of NF-κB/IL-6/JAK1/STAT3 (! Polysaccharide isolated from jujube extract slightly inhibited NF-κB activity the trophic ingredients having potential beneficial of... Important phytochemical detected in ample amounts in the renal interstitium enzymes in determining the iron recycling were! Two pectic polysaccharides from organs of Chinese jujube and fatty acid composition of four promising jujube ( Ziziphus Mill... Circulating EPO is produced by adult kidney cells ; while kidney dysfunction contributes to chronic inflammation small of! Potential hematopoietic activity with jujube extract attenuated blood pressure and mean arterial pressure L-NAME-induced! 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